Blamed for the terrorist bombing of the Kremlin, IMF operative Ethan Hunt is disavowed along with the rest of the agency when the President initiates "Ghost Protocol". Left without any resources or backup, Ethan must find a way to clear his agency's name and prevent another attack. To complicate matters further, Ethan is forced to embark on this mission with a team of fellow IMF fugitives whose personal motives he does not fully know.

The small town of Pacashau, Georgia, has fallen on hard times, but the people are counting on the Divinity Church Choir to lift their spirits by winning the National Joyful Noise Competition. The choir has always known how to sing in harmony, but the discord between its two leading ladies now threatens to tear them apart. Their newly appointed director, Vi Rose Hill, stubbornly wants to stick with their tried-and-true traditional style, while the fiery G.G. Sparrow thinks tried-and-true translates to tired-and-old.

The Chipmunks and The Chipettes (three female counterparts to the Chipmunks) go on a cruise trip with the Chipmunks' owner/manager/father figure, Dave Seville. During the cruise, the 'Munks and 'Ettes turn the ship into their personal playground, causing trouble and running amuck as they will. Eventually, their chaotic behavior gets them ship wrecked on the Isles of Scilly, everyone getting lost in the process. As Dave sets out to look for the lost chipmunk trios, the six find a new castaway on the island who turns out to be more than a match for the trios.